Table 4.

Multivariate Cox regression analysis for prognostic association of CASP1 in B-ALL patients.

Variables	Relapse free survival			Event free survival			Overall survival
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Age at diagnosis
<10 years	Ref			Ref			Ref
≥10 years	3.502	1.392–8.808	0.008	3.683	1.811–7.490	0.000	3.037	1.174–7.858	0.022
Sex
Male	Ref			Ref			Ref
Female	1.946	0.760–4.981	0.165	1.295	0.643–2.611	0.468	0.775	0.306–1.965	0.593
WBC count (X109/L)
<50	Ref			Ref			Ref
≥50	1.710	0.628–4.653	0.293	1.779	0.866–3.656	0.117	1.924	0.733–5.049	0.183
Cytogenetics
ETV6-RUNX1/Hyperdiploidy	Ref			Ref			Ref
BCR-ABL/E2A-PBX1/Hypodiploidy	5.881	1.452–23.823	0.013	3.243	1.160–9.064	0.025	1.977	0.467–8.374	0.354
B-others	0.976	0.298–3.197	0.969	0.917	0.394–2.131	0.841	0.920	0.280–3.023	0.891
Minimal residual disease (MRD)
Negative	Ref			Ref			Ref
Positive	3.312	1.681–6.527	0.001	2.193	1.332–3.608	0.002	1.249	0.597–2.612	0.554
Cerebrospinal fluid
Negative	Ref			Ref			Ref
Positive	1.054	0.100–11.098	0.964	3.472	1.118–10.780	0.031	5.910	1.557–22.438	0.009
NCI risk
Standard risk	Ref			Ref			Ref
High risk	0.440	0.160–1.211	0.112	0.612	0.280–1.336	0.218	0.767	0.242–2.425	0.652
Prednisolone response
Sensitive	Ref			Ref			Ref
Resistant	0.654	0.186–2.296	0.508	1.410	0.658–3.021	0.376	1.579	0.600–4.156	0.355
CASP1 expression
Low	Ref			Ref			Ref
High	1.268	0.548–2.933	0.578	0.622	0.323–1.198	0.156	0.425	0.182–0.990	0.048

Bold values highlights significant associations.