Table 5.

Multivariate Cox regression analysis for prognostic association of NLRP3 in B-ALL patients.

Variables	Relapse free survival			Event free survival			Overall survival
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Age at diagnosis
<10 years	Ref			Ref			Ref
≥10 years	3.866	1.547–9.657	0.004	3.904	1.900–8.021	0.000	3.192	1.187–8.581	0.021
Sex
Male	Ref			Ref			Ref
Female	2.106	0.853–5.194	0.106	1.293	0.651–2.565	0.462	0.731	0.297–1.799	0.495
WBC count (X109/L)
<50	Ref			Ref			Ref
≥50	1.574	0.588–4.212	0.366	1.817	0.894–3.691	0.099	1.512	0.559–4.088	0.415
Cytogenetics
ETV6-RUNX1/Hyperdiploidy	Ref			Ref			Ref
BCR-ABL/E2A-PBX1/Hypodiploidy	6.122	1.558–24.046	0.009	3.224	1.145–9.078	0.027	1.721	0.395–7.497	0.469
B-others	1.112	0.354–3.486	0.855	0.809	0.350–1.872	0.622	0.901	0.274–2.957	0.864
Minimal residual disease (MRD)
Negative	Ref			Ref			Ref
Positive	3.393	1.720–6.696	0.000	2.288	1.395–3.753	0.001	1.358	0.649–2.840	0.416
Cerebrospinal fluid
Negative	Ref			Ref			Ref	1.607–
Positive	1.692	0.158–18.015	0.663	4.169	1.336–13.014	0.014	6.236	24.186	0.008
NCI risk
Standard risk	Ref			Ref			Ref
High risk	0.414	0.151–1.136	0.087	0.571	0.258–1.263	0.167	0.811	0.250–2.625	0.727
Prednisolone response
Sensitive	Ref			Ref			Ref
Resistant	0.613	0.174–2.150	0.445	1.464	0.684–3.133	0.326	1.802	0.711–4.565	0.214
NLRP3 expression
Low	Ref			Ref			Ref
High	0.688	0.247–1.914	0.475	0.439	0.236–0.818	0.010	0.310	0.126–0.766	0.011

Bold values highlights significant associations.