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. 2021 Feb 19;49:101193. doi: 10.1016/j.molmet.2021.101193

Figure S2.

Figure S2

Activation of α-cell GCK enhances glucose-suppression of glucagon secretion (GSGS) in isolated pancreatic islets from adult female mice. (A) Glucagon secretion and (B) content from isolated pancreatic islets in the presence of the indicated glucose concentrations with 4 mM amino acid mixture or 30 mM KCl. (C) Insulin secretion and (D) content from isolated pancreatic islets in the presence of the indicated glucose concentrations with 4 mM amino acid mixture or 30 mM KCl. (∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001 vs. genetically unmodified control). Analysis by two-way ANOVA with post hoc Bonferroni test.