Skip to main content
. 2021 Feb 19;49:101193. doi: 10.1016/j.molmet.2021.101193

Figure 2.

Figure 2

Activation of α-cell GCK enhances glucose-suppression of glucagon secretion (GSGS) in isolated pancreatic islets from male mice.(A) Glucagon secretion and (B) content from isolated pancreatic islets in the presence of the indicated glucose concentrations with 4 mM amino acid mixture or 30 mM KCl. (C) Insulin secretion and (D) content from isolated pancreatic islets in the presence of the indicated glucose concentrations with 4 mM amino acid mixture or 30 mM KCl. (∗∗p < 0.01, ∗∗∗∗p < 0.0001 vs. genetically unmodified control). Analysis by two-way ANOVA with post hoc Bonferroni test.