Figure 4.

Mice with activated α-cell GCK have normal islet morphology.(A) Insulin, glucagon, and EdU shown by co-immunofluorescence (40×). Scale bar: 50 μm. (B) Glucagon⁺, EdU⁺ cells as a percentage of total Glucagon⁺ cells (n = 4 for each genotype). (C) Insulin⁺, EdU⁺ cells as a percentage of total Insulin⁺ cells. (n = 4 for each genotype) (D) Insulin, glucagon, and CgA shown by co-immunofluorescence (40×). Scale bar: 50 μm. (E) Glucagon⁺, CgA⁺ cells as a percentage of total CgA⁺ cells (n = 4 for each genotype). (F) Insulin⁺, CgA⁺ cells as a percentage of total CgA⁺ cells (n = 4 for each genotype).