Table 1.
Comparison of clinicopathologic features between NECs and ACs after matching tumour site.
| 30 NECs | 100 ACs | p value | |
|---|---|---|---|
| Number (%) | Number (%) | ||
| Age (years), median (range) | 67 (44–83) | 62 (33–81) | 0.07 |
| Sex | |||
| Male | 20 (67) | 57 (57) | 0.4011 |
| Female | 10 (33) | 43 (43) | |
| Underlying disease | |||
| HNPCC | 1 (3) | 0 | |
| FAP | 1 (3) | 0 | |
| Tumor location | |||
| Right-sided | 9 (30) | 30 (30) | |
| Left-sided | 7 (23) | 23 (23) | |
| Rectum | 14 (47) | 47 (47) | |
| Tumor size (cm), median (range) | 5.65 (1.6–16) | 5.4 (0.5–15) | 0.1535 |
| Tumor differentiation | |||
| Low grade | 89 | ||
| High grade | 30 | 11 | |
| Histologic subtype | |||
| Small cell | 12 (40) | ||
| Large cell | 18 (60) | ||
| Mitoses/2 mm2, median (range) | 62.5 (12–141) | ||
| Ki-67 index(%), median (range) | 75 (50–95) | ||
| Coexisting component | |||
| Adenocarcinoma | 7 (23) | ||
| Tubular adenoma | 3 (10) | ||
| Depth of invasion | |||
| T1 | 1 (3) | 6 (6) | 0.1247 |
| T2 | 4 (13) | 12 (12) | |
| T3 | 19 (63) | 76 (76) | |
| T4 | 6 (20) | 6 (6) | |
| Lymphatic invasion | |||
| No | 1 (3) | 59 (59) | < 0.0001 |
| Yes | 29 (97) | 41 (41) | |
| Vascular invasion | |||
| No | 7 (23) | 80 (80) | < 0.0001 |
| Yes | 23 (77) | 20 (20) | |
| N category | |||
| N0 | 6 (20) | 47 (47) | 0.0001 |
| N1 | 6 (20) | 33 (33) | |
| N2 | 18 (60) | 20 (20) | |
| M category | |||
| M0 | 9 (30) | 91 (91) | 0.0001 |
| M1 | 11 (37) | 14 (14) | |
| Metastatic sites | |||
| Liver | 6 (20) | 7 (7) | > 0.9999 |
| Others | 5 (17) | 7 (7) | |
| Pathologic AJCC stage | |||
| I/II | 5 (17) | 45 (45) | 0.0053 |
| III/IV | 25 (83) | 55 (55) | |
HNPCC hereditary nonpolyposis colorectal cancer, FAP familial adenomatous polyposis.