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. 2021 Mar 18;11:6203. doi: 10.1038/s41598-021-85593-9

Table 2.

Comparison of immunohistochemistry and microsatellite instability status between NECs and ACs.

NEC AC p value
Total number (%) 30 (100) 100 (100)
P53
Intact 17 (57) 65 (65) 0.518
Aberrant 13 (43) 35 (35)
RB1
Negative 14 (47) 100 (100)
Positive 16 (53) 0
P16
Negative 13 (43) 97 (97)  < 0.0001
Positive 17 (57) 3 (3)
MMR proteins
Intact 29 (97) 93 (93) 0.6807
Loss 1 (3) 7 (7)
MSI
MSS 28 (93) 92 (92) 0.5155
MSI-L 1 (3) 1 (1)
MSI-H 1 (3) 7 (7)

MMR mismatch repair, MSI microsatelllite instability testing, MSS microsatellite stable, MSI-L microsatellite instability-low, MSI-H microsatellite instability-high.