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. 2021 Mar 5;12:641894. doi: 10.3389/fphar.2021.641894

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Copyright © 2021 Ma, Xie, Li, Guo, Wang, Li, Ren, Gong and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustration of pathological changes using HE staining (n = 3). (A) HE results of each group, (B) Semi-quantitative analysis of pathological injury, (C) Semi-quantitative analysis of pathological repair. Red arrow represents red neuron, black arrow represents liquefied and necrotic nerve tissue, yellow arrow represents microglia clears out necrotic neurons, green arrows represents new blood vessels, ^** p < 0.01, compared with the control group; ^# p < 0.05, ^## p < 0.01, compared with the vehicle group.