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. 2021 Mar 18;11:6308. doi: 10.1038/s41598-021-85560-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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HP1D3csd affects the ability of Phf7 to induce germline masculinization in a dose-dependent manner. (a,b), Example of a pseudotestis with its XX germ cells overexpressing both Phf7 and HP1D3csd (UAS-Phf7.FL, UAS-HP1D3csd.HA, Δtra/tra¹, nos-Gal4) that exhibited “partial rescue” of spermatogenesis. Vas is in green and N-cad is in red. (a), View of the entire pseudotestis. (b), View of the pseudotestis apical tip. (c), Quantitation of the different types of phenotypes observed for pseudotestes with XX germ cells overexpressing Phf7 and either HP1D3csd or a control construct (LacZ). The numbers in the graph indicate sample sizes. * indicates P < 0.05 with chi-square tests. (d,e), A pseudotestis overexpressing Phf7 but lacking a functional copy of HP1D3csd (HP1D3csd^f07323/ + ; UAS-Phf7.FL, Δtra/tra¹, nos-Gal4) exhibiting “partial rescue” of spermatogenesis. Vas is in green and N-cad is in red. (d), Image of the entire pseudotestis. (e), Image of the pseudotestis apical tip. (f), Quantitation of the different types of phenotypes observed for pseudotestes with their XX germ cells overexpressing Phf7 and either wildtype or harboring a mutant copy of HP1D3csd. The numbers in the graph indicate sample sizes. * indicates P < 0.05 with chi-square tests.