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. 2021 Mar 18;11:6288. doi: 10.1038/s41598-021-85778-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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HIF2-EPO-EPO-R response of CKD mice with uncontrolled IL1 expression. Experimental groups include: wild type mice on a regular (WT) or adenine diet (WT-CKD), IL1-R antagonist knockout mice on regular diet (RaKO) or adenine (RaKO-CKD). Kidney hypoxia-inducible factor 2α (HIF2a) mRNA levels (A) and protein levels (normalized for β-actin). The lower panel shows a representative gel (B). Serum erythropoietin (EPO) levels (pg/mL) (C). Bone marrow EPO receptor (EPOR) (D) and transferrin receptor (TFR) (E) mRNA levels. n = 6–10 per group. Different letters above bars indicate a significant difference between groups, similar letters indicate no significant difference.