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. 2021 Mar 18;11:6288. doi: 10.1038/s41598-021-85778-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Renal inflammatory response of CKD mice to IL1 inhibition. Kidney inflammation in mice on regular (C) or adenine diet, injected with saline (CKD) or anti-IL1 monoclonal antibody (CKD-Ab). Kidney Interleukin-1β (A), IRAK-4 (B), MYD-88 (C), c-MYC (D), Kidney TNF-α (E), Interleukin-10 (IL10) (F), and interleukin-6 (IL6) (G) mRNA levels. Kidney p-STAT3/STAT3 protein ratio (normalized for β-actin). The lower panel shows a representative gel (H). n = 7–10 animals per group. Different letters above bars indicate a significant difference between groups, similar letters indicate no significant difference.