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. 2021 Mar 18;11:6350. doi: 10.1038/s41598-021-85788-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed model for the serum metabolic changes observed in COVID-19 patients. Red arrows represent metabolic flux inhibited during hypoxia. Blue arrows represent increased flux in hypoxia. ME Malic enzyme. The graphs were constructed with the normalized values from control subjects (C), mild (M), and severe (S) patients. Asterisks indicate statistical significance according to the Dunn test. p* < 0.05 ** < 0.01, *** < 0.001, **** < 0.0001.