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. 2021 Mar 18;11:6227. doi: 10.1038/s41598-021-84421-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Isotopologue profiling with regard to ¹³C in alanine, aspartate, glutamate, glycine, proline, and serine following incubation of EJ28Luc cells with ²¹³Bi-anti-EGFR-MAb compared to untreated controls. Just as in Fig. 2 showing overall enrichment of ¹³C, a significantly lower enrichment of ¹³C in the various C-atoms following ²¹³Bi-anti-EGFR-MAb treatment was only observed for alanine, aspartate, glutamate, and serine but not for glycine and proline. SHMT serine hydroxymethyl transferase, ALT alanine aminotransferase, PC pyruvate carboxylase, PDH pyruvate dehydrogenase.