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. 2021 Mar 18;11:6254. doi: 10.1038/s41598-021-82602-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor-specific targeting and NIRF imaging of IR780-NBs-DTX in subcutaneous xenotransplanted pancreatic cancer in vivo. (a) Nude mice bearing tumors derived from the Mia-Paca2 cell line were detected via the IVIS Lumina II system at 1 h after being injected with different contrast agents. The yellow dotted lines represent the tumor outline. (b) Comparison of the average fluorescence intensity of tumors in different groups. *P < 0.05, significantly different from the average fluorescence intensity of tumors in the saline group, NBs (FITC) group and IR-780 iodide group. (c) Immunofluorescence detection of tumor tissues for the IR780-NBs-DTX” group at 1 min, 5 min and 1 h after injection of contrast agents through the caudal vein.