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. 2021 Mar 18;11:6254. doi: 10.1038/s41598-021-82602-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CEUI of IR780-NBs-DTX on subcutaneous xenotransplanted pancreatic cancer in vivo. (a) Nude mice bearing subcutaneous xenotransplanted pancreatic cancer. (b) Routine ultrasound for pancreatic cancer. (c) CEUI of pancreatic cancer mediated by IR780-NBs-DTX and SonoVue. The red dotted lines represent the tumor outline. (d) Analysis of the time-dependent echo intensity of CEUI mediated by IR780-NBs-DTX and SonoVue in pancreatic cancer. *P < 0.05, significantly different from the echo intensity of CEUI mediated by SonoVue at 150 s.