Table 4.

The sensitivity analysis for the adjusted hazard ratio (95% C.I.) stratified by follow up time, sex and age groups after PSM.

	aHR (95% C.I.) of HCN
	Control	Peptic ulcer
		Total	Untreated	Treated
Overall follow up time
Sex subgroups
Female	Reference	1.01(0.76–1.35)	1.20(0.87–1.64)	0.71(0.46–1.11)
Male	Reference	1.10(0.97–1.25)	1.23(1.07–1.43)	0.93(0.78–1.11)
Age at index date
< 30 years old	Reference	1.94(0.86–4.35)	2.57(1.13–5.89)	0.68(0.15–3.13)
30–44 years old	Reference	1.16(0.91–1.49)	1.35(1.02–1.78)	0.95(0.68–1.32)
45–64 years old	Reference	1.13(0.96–1.33)	1.29(1.07–1.55)	0.95(0.76–1.18)
≥ 65 years old	Reference	0.89(0.69–1.13)	0.96(0.73–1.25)	0.74(0.51–1.08)
Urbanization
Urban	Reference	1.21(1.03–1.43)	1.44(1.20–1.72)	0.94(0.76–1.17)
Sub-urban	Reference	0.96(0.78–1.19)	1.04(0.82–1.32)	0.86(0.65–1.14)
Rural	Reference	0.93(0.68–1.28)	1.00(0.70–1.42)	0.83(0.53–1.29)
Hospitalization at baseline
No	Reference	0.97(0.84–1.12)	1.07(0.90–1.26)	0.85(0.71–1.03)
Yes	Reference	1.39(1.12–1.72)	1.60(1.27–2.01)	1.00(0.73–1.38)
Follow up > 6 years
Sex subgroups
Female	Reference	1.12(0.69–1.81)	1.31(0.77–2.22)	0.85(0.43–1.69)
Male	Reference	1.27(1.02–1.58)	1.48(1.15–1.89)	1.03(0.77–1.37)
Age at index date
< 30 years old	Reference	1.39(0.44–4.39)	1.88(0.58–6.18)	0.54(0.06–4.63)
30–44 years old	Reference	1.54(1.07–2.23)	1.86(1.24–2.80)	1.21(0.76–1.93)
45–64 years old	Reference	1.14(0.85–1.53)	1.37(0.98–1.91)	0.91(0.62–1.34)
≥ 65 years old	Reference	1.07(0.69–1.68)	1.11(0.68–1.81)	1.02(0.55–1.86)
Urbanization
Urban	Reference	1.29(0.98–1.69)	1.59(1.17–2.16)	0.95(0.66–1.37)
Sub-urban	Reference	1.19(0.84–1.69)	1.37(0.92–2.02)	0.97(0.61–1.55)
Rural	Reference	1.20(0.71–2.05)	1.13(0.61–2.10)	1.31(0.68–2.54)
Hospitalization at baseline
No	Reference	1.19(0.94–1.50)	1.38(1.06–1.80)	0.98(0.73–1.33)
Yes	Reference	1.37(0.94–2.02)	1.60(1.05–2.44)	1.04(0.61–1.79)

PSM, propensity score matched; HNC, head and neck cancer.