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. 2021 Mar 18;11:6246. doi: 10.1038/s41598-021-85775-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Platelet reactivity after collagen (CRP-XL) and ADP stimulation. (A) Platelet fibrinogen binding is depicted as mean fluorescence intensity (MFI) after ex vivo stimulation with platelet agonist collagen-related peptide (CRP-XL; 33 ng/mL; 625 ng/mL) and adenosine diphosphate (ADP; 1.2 μM, 125 μM). (B) Platelet degranulation measured by P-selectin expression is depicted as mean fluorescence intensity (MFI) after ex vivo stimulation with CRP-XL (33 ng/mL; 625 ng/mL) and ADP (1.2 μM, 125 μM). Data are shown as dotplot with error bars median and interquartile range (IQR). Data were analyzed using unpaired Student’s T-test. People living with HIV (PLHIV); healthy controls (HC).