Table 3.
Detailed results of the markers for senescence and autophagy in UIP/IPF and UIP/AuD
| Degenerative/remodeled epithelium | Myofibroblasts | Normal pneumocytes | Bronchial epithelium | Endothelium | Smooth muscle cells | Macrophages | ||
|---|---|---|---|---|---|---|---|---|
| Senescence | ||||||||
| p21 | UIP/IPF* | 9/9 | 1/9 | 8/9 | 0/9 | 0/9 | 0/9 | 0/9 |
| UIP/AuD | 13/13 | 0/13 | 13/13 | 6/13 | 0/13 | 0/13 | 0/13 | |
| p16 | UIP/IPF* | 9/9 | 0/9 | 1/9 | 0/9 | 0/9 | 0/9 | 0/9 |
| UIP/AuD | 13/13 | 1/13 | 0/13 | 0/13 | 0/13 | 0/13 | 1/13 | |
| Autophagy | ||||||||
| SIRT1 | UIP/IPF | 10/10 | 7/10 | 7/10 | 6/10 | 0/10 | 0/10 | 10/10 |
| UIP/AuD | 13/13 | 12/13 | 11/13 | 9/13 | 3/13 | 0/13 | 12/13 | |
| MAP1S | UIP/IPF | 10/10 | 4/10 | 8/10 | 7/10 | 4/10 | 0/10 | 10/10 |
| UIP/AuD | 13/13 | 6/13 | 7/13 | 7/13 | 2/13 | 0/13 | 12/13 | |
| LC3 | UIP/IPF | 10/10 | 10/10 | 10/10 | 10/10 | 9/10 | 0/10 | 10/10 |
| UIP/AuD | 13/13 | 12/13 | 13/13 | 13/13 | 8/13 | 3/13 | 13/13 | |
| pAMPKα | UIP/IPF | 10/10 | 9/10 | 9/10 | 10/10 | 2/10 | 2/10 | 10/10 |
| UIP/AuD | 13/13 | 13/13 | 13/13 | 12/13 | 2/13 | 1/13 | 13/13 | |
•In one case, the relevant lesions were not anymore present in some of the serial sections; therefore, this case was excluded from the evaluation