Table 3.
Determination of Minimum Inhibitory Concentrations for Laboratory Strain PAO1 and Clinical Isolates Exhibiting the Serum-Associated Antibiotic Tolerance Phenotype Before and After Exposure to Serum + Antibiotic
| Strain | Antibiotica | MIC LB-pre Serum (µg/mL) | MIC Serum (µg/mL) | MIC LB-post Serum (µg/mL) |
|---|---|---|---|---|
| PAO1 | Minocycline | 8 | >32 | 8 |
| JHACHPA15 | Minocycline | 8 | >32 | 8 |
| Tobramycin | 2 | 8 | 2 | |
| JHACHPA37 | Minocycline | 16 | >32 | 16 |
| Tobramycin | 1 | >1 | 1 | |
| JHACHPA39 | Minocycline | 16 | >32 | 16 |
Abbreviation: LB, Luria-Bertani; MIC, minimum inhibitory concentration.
a Minimum inhibitory concentrations determined only for antibiotics to which the strain exhibited serum-associated antibiotic tolerance.