Table 4.
Baseline Patient Characteristics, Admitting Diagnoses, and Chronic Diagnoses by Serum-Associated Antibiotic Tolerance Status
| Baseline Characteristic | SAT-Negative (n = 15) | SAT-Positive (n = 29) | P Value |
|---|---|---|---|
| Patient age at admission, median (IQR), y | 9.8 (2.6,16.7) | 12.6 (8.0,16.4) | .34 |
| Sex, n (%) | .34 | ||
| Male | 5 (33.3) | 15 (51.7) | … |
| Female | 10 (66.7) | 14 (48.3) | … |
| Admitting diagnoses, n (%)a | |||
| Cough | 1 (6.7) | 7 (24.1) | .23 |
| Fever | 2 (13.3) | 4 (13.8) | 1.0 |
| Hypoxia | 4 (26.7) | 6 (20.7) | .71 |
| Pneumonia | 3 (20.0) | 8 (27.6) | .72 |
| Respiratory distress | 5 (33.3) | 9 (31.0) | 1.0 |
| Tachypnea | 0 (0.0) | 1 (3.5) | 1.0 |
| Cystic fibrosis/exacerbation | 4 (26.7) | 10 (34.5) | .74 |
| Tracheitis | 1 (6.7) | 5 (17.2) | .65 |
| Other | 8 (53.3) | 22 (75.9) | .18 |
| Chronic diagnoses, n (%) | |||
| Respiratory diagnoses | |||
| Other respiratoryb | 13 (86.7) | 21 (72.4) | .45 |
| Cystic fibrosis | 4 (26.7) | 10 (34.5) | .74 |
| Tracheostomy dependence | 4 (26.7) | 10 (34.5) | .74 |
| Neurologic diagnosesc | 11 (73.3) | 22 (75.9) | 1.0 |
| Cardiac diagnosesd | 2 (13.3) | 2 (6.9) | .60 |
| Gastrointestinal diagnosese | 13 (86.7) | 25 (86.2) | 1.0 |
| Immunosuppressedf | 0 (0.0) | 3 (10.3) | .54 |
| Renal diagnoses | 0 (0.0) | 2 (6.9) | .54 |
| Hepatic diagnoses | 1 (6.7) | 2 (6.9) | 1.0 |
Abbreviation: SAT, serum-associated antibiotic tolerance.
a Patients could have had multiple admitting or chronic diagnoses.
b Asthma, bronchopulmonary dysplasia (BPD), chronic lung disease (CLD), home respiratory support.
c Cerebral palsy, developmental delay, hydrocephalus, intellectual disability, nonambulatory, and/or ventriculoperitoneal shunt.
d Congenital heart disease, pulmonary hypertension.
e Aspiration, feeding-tube dependency, gastric fundoplication, supplemental nutrition requirement.
f Immunosuppressed due to medication, genetic, or both medication and genetic.