Fig 20.

CJD in a 51-year-old man with progressive dementia. (From Moritani T, Ekholm S, Westesson PL. Diffusion-Weighted MR Imaging of the Brain. Berlin: Springer-Verlag; 2004. Used with permission.)

A, T2-weighted image demonstrates mild hyperintensity bilaterally in the caudate nuclei, putamina, and pulvinar of the thalami (arrows).

B, DW image clearly demonstrates hyperintense lesions in these areas.

C, ADC is decreased in these lesions, which may represent cellular edema. The distribution of these lesions may be related to dysfunction of glutamate receptors.