Table 2.
Cross-sectional group-comparisons of OCT- and DTI-measures.
| NMO-ON | NMO-NON | HC | ANCOVA | NMO-ON vs. NMO-NON | NMO-ON vs. HC | NMO-NON vs. HC | |
|---|---|---|---|---|---|---|---|
| Mean pRNFL thickness at baseline, µm | 72.3 ± 20.5 (n = 15) |
98.5 ± 12.2 (n = 12) |
95.6 ± 11.3 (n = 17) |
F = 12.30 p < 0.001 |
B = −26.9 (SE = 6.4) p < 0.001 |
B = –23.3 (SE = 5.8) p < 0.001 |
B = 3.6 (SE = 6.8) p = 0.862 |
| Mean GCIPL thickness at baseline, µm | 62.0 ± 10.3 (n = 15) |
76.7 ± 5.1 (n = 11) |
78.7 ± 7.1 (n = 17) |
F = 18.29 p < 0.001 |
B = −15.4 (SE = 3.3) p < 0.001 |
B = −16.3 (SE = 3.1) p < 0.001 |
B = −0.9 (SE = 3.6) p = 0.965 |
| Mean OR-FA at baseline | 0.484 ± 0.03 (n = 11) |
0.505 ± 0.03 (n = 10) |
0.510 ± 0.03 (n = 14) |
F = 2.32 p = 0.116 |
B = −0.03 (SE = 0.01) p = 0.133 |
B = −0.02 (SE = 0.01) p = 0.254 |
B = 0.01 (SE = 0.01) p = 0.887 |
| Mean OR-MD at baseline | 0.941 ± 0.10 (n = 11) |
0.90 ± 0.07 (n = 10) |
0.955 ± 0.09 (n = 14) |
F = 1.51 p = 0.238 |
B = 0.05 (SE = 0.04) p = 0.463 |
B = −0.02 (SE = 0.04) p = 0.814 |
B = −0.07 (SE = 0.04) p = 0.214 |
| Mean OR-RD at baseline | 0.688 ± 0.11 (n = 11) |
0.635 ± 0.07 (n = 10) |
0.685 ± 0.09 (n = 14) |
F = 1.48 p = 0.244 |
B = 0.06 (SE = 0.04) p = 0.335 |
B = −0.01 (SE = 0.04) p = 0.972 |
B = −0.07 (SE = 0.04) p = 0.260 |
| Mean OR-AD at baseline | 1.447 ± 0.10 (n = 11) |
1.418 ± 0.06 (n = 10) |
1.494 ± 0.11 (n = 14) |
F = 1.76 p = 0.190 |
B = 0.03 (SE = 0.04) p = 0.781 |
B = −0.05 (SE = 0.04) p = 0.415 |
B = −0.08 (SE = 0.05) p = 0.181 |
| Mean OR-FA at last visit | 0.468 ± 0.04 (n = 17) |
0.507 ± 0.03 (n = 11) |
0.514 ± 0.03 (n = 16) |
F = 7.15 p = 0.002 |
B = −0.04 (SE = 0.01) p = 0.014 |
B = −0.04 (SE = 0.01) p = 0.007 |
B = −0.0003 (SE = 0.02) p > 0.999 |
| Mean OR-MD at last visit | 1.022 ± 0.17 (n = 17) |
0.888 ± 0.06 (n = 11) |
0.940 ± 0.10 (n = 16) |
F = 4.05 p = 0.025 |
B = 0.12 (SE = 0.05) p = 0.041 |
B = 0.09 (SE = 0.04) p = 0.104 |
B = −0.03 (SE = 0.05) p = 0.860 |
| Mean OR-RD at last visit | 0.771 ± 0.18 (n = 17) |
0.627 ± 0.06 (n = 11) |
0.670 ± 0.10 (n = 16) |
F = 4.77 p = 0.014 |
B = 0.13 (SE = 0.05) p = 0.029 |
B = 0.11 (SE = 0.05) p = 0.058 |
B = −0.02 (SE = 0.06) p = 0.903 |
| Mean OR-AD at last visit | 1.524 ± 0.16 (n = 17) |
1.410 ± 0.08 (n = 11) |
1.479 ± 0.11 (n = 16) |
F = 2.40 p = 0.104 |
B = 0.10 (SE = 0.05) p = 0.111 |
B = 0.06 (SE = 0.04) p = 0.350 |
B = −0.04 (SE = 0.05) p = 0.772 |
For all measures the mean ± standard deviation is shown; they all represent the mean of both sides (for OCT-measures: both eyes and for DTI-measures: both cerebral hemispheres). Note that due to reduced number of participants with baseline DTI-data (n = 12 missing), we also performed the cross-sectional group comparisons at the last follow-up visit (only n = 3 missing). These results are shown below the baseline DTI- results (“at last visit”). Significant results are marked in bold.
Abbreviations: AQP4-IgG = Aquaporin-4 immunoglobulin-G, DTI = diffusion-tensor imaging, GCIPL = ganglion cell-inner plexiform layer, HC = healthy controls, NMO-NON: patients without previous optic neuritis, NMO-ON = patients with previous optic neuritis, OCT = optical coherence tomography, ON = optic neuritis, OR-AD: axial diffusivity of the optic radiations, OR-FA: fractional anisotropy of the optic radiations, OR-MD = mean diffusivity of the optic radiations, OR-RD: radial diffusivity of the optic radiations, pRNFL = peripapillary retinal nerve layer