Table 1.
Results of the anatomical likelihood estimation meta-analyses for healthy ageing (n = 18 experiments with a total of 2441 subjects and k = 64 foci of cerebellar grey matter decline), Alzheimer’s disease (n = 13 experiments with a total of 529 subjects and k = 35 foci of cerebellar decline), and the conjunction which identified the spatial overlap between effects of Alzheimer’s disease and age on cerebellar structure. Here we report the Montreal Neurological Institute coordinates returned by GingerALE. Labels are according to the spatially unbiased atlas template of the cerebellum and brainstem (SUIT).
| Cluster number | Peak MNI coordinates | Extent | Cluster size (mm3) | p-value | Local extrema | Peak Label | Notes |
|---|---|---|---|---|---|---|---|
| Healthy ageing | |||||||
| 1 | 33 -81 -37 | 24 -90 -42 to 40 -72 -30 |
1504 | .018 .015 |
36 -80 -38 30 -88 -34 |
R Crus II | |
| 2 | 35 -63 -29 | 28 -70 -34 to 42 -56 -22 |
1464 | .018 |
36 -60 -30 | R Crus I | Extends into VI |
| 3 | -35 -77 -40 | -46 -86 -44 to -28 -68 -34 |
1288 | .018 .016 .011 |
-34 -82 -38 -34 -72 -40 -42 -76 -40 |
L Crus II | |
| 4 | 1 -72 -15 | -10 -78,-22 to 8,-66,-10 |
1112 | .015 .012 |
4 -74 -14 -8 -70 -14 |
Vermal lobule VI L lobule VI |
|
| 5 | -40 -42 -41 | -48 -54 -46 to -34 -36 -36 |
808 | .019 .011 .011 |
-38 -40 -40 -46 -48 -42 -46 -52 -44 |
L Crus II L Crus I L Crus II |
Extends into VIIb/VIII |
| Alzheimer’s disease | |||||||
| 1 |
30 -71 -31 |
26 -78 -40 to 34 -62 -24 |
1144 | .014 |
30 -68 -38 |
R Crus I, Crus II |
|
| 2 | 38 -61 -25 | 30 -66 -32 to 44 -58 -20 |
856 | .015 | 40 -62 -24 | R lobule VI, Crus I | |
| Conjunction of age and Alzheimer’s disease | |||||||
| 1 | 36 -62 -27 | 30 -66 -32 to 40 -58 -22 |
408 | .013 | 36 -62 -26 | R lobule VI | Extends into Crus I |
| 2 | 32 -72 -38 | 8 | .008 | Crus II | |||
| 3 | 30 -68 -30 | 8 | .008 | Crus I | |||