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. 2021 Mar 12;23(5):358. doi: 10.3892/mmr.2021.11997

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Copyright: © Hu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — ox-LDL induces Lp-PLA₂ expression and inhibits CSE expression in THP-1 cells. Cells were treated with 50 µg/ml ox-LDL for 24 h. Relative protein expression levels of (A) Lp-PLA₂ and (B) CSE were determined via western blot analysis. Relative mRNA expression levels of (C) Lp-PLA₂ and (D) CSE were determined via reverse transcription-PCR. (E) Activity levels of Lp-PLA₂ were determined using a Lp-PLA₂ activity kit. (F) CSE activity was determined with a methylene blue spectrophotometric assay. The data are presented as the mean ± SEM (n=5). **P<0.01 vs. control. ox-LDL, oxidized low-density lipoprotein; Lp-PLA₂, lipoprotein-associated phospholipase A2; CSE, cystathionine γ-lyase.