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. Author manuscript; available in PMC: 2021 Mar 19.
Published in final edited form as: Annu Rev Immunol. 2017 Feb 9;35:533–550. doi: 10.1146/annurev-immunol-110416-120628

Figure 1.

Figure 1

Receptors for γc family cytokines. Shown are the receptors for IL-2, -15, -4, -7, -9, and -21. The receptors share the γc chain and express a cytokine-specific a chain. Furthermore, IL-2 and IL-15 use a third receptor chain, the IL-2/IL-15R β chain. The receptors for each γc family cytokine activate JAK1 and JAK3. The STAT activated by the cytokine receptors is shown, with STAT5 referring to both STAT5A and STAT5B. Abbreviations: DC, dendritic cell; NK cell, natural killer cell; NKT cell, natural killer T cell. Modified from Figure 1 in Reference 1, with permission.