Table 1.

JAK and STAT mutations in T cell lymphoma

T cell disease	JAK mutation	STAT mutation	Other mutations/fusions	Reference(s)
Extranodal NKTCL	JAK1: Y652D JAK3: C565DEL, A572V, A573V, V722I	STAT3: S614R, D66IY, A703T, STAT5B: N642H, Y665F		20, 22, 23
Hepatosplenic γδTCL		STAT3: Y640F, D661Y STAT5B: N642H, Y665F, E679K		23
CTCL, including Sézary syndrome	JAK1: Y654F, L710VJAK3: Y123H, A573V, S989I	STAT3: I498Y, Y640F STAT5B: N642H, Q706L		26, 30, 58
HTLV-1 ATLL	JAK3: L156P, R172Q, E183G			34,64
PTCL-NOS	JAK3: L1073F	STAT5B: Q743H	IL-7RQ445*	95
ETP-ALL	JAK1: S512L, A634D, V658F, R724H/Q, V782M, L783F, R879S/C/H JAK2: R683S/G/Q, I682F, R867Q, D873N, P933R JAK3: V715ITYK2: V15A, G36D, S47N, R274H, R425H, V731I, E957D, R1027H		IL-7R, TEL-JAK2	31,35,37, 65, 69, 70
AITL	JAK2: V617F, G511S	614,661		32
NK, LGL leukemia	JAK1: Y652DJAK3: C365del, A572V, A573V, V722I, L1073F	STAT3: S614R, G618R, Y640F, N647I, D661Y/VHI, STAT5B: N642H, Y665F		13–15, 59
ALK-negative ALCL	JAK1: G1097D/S/V, Y640F, L910P	STAT3: S614R, G618R, Y640F, N647I, D661H/Y, lins, A662V	NFB2-ROS1, NFB2-TYK2, PABPC4-TYK2, lead to constitutive pSTAT3 activation	16–18, Chen etal. 2016^a
T-PLL	JAK1: L653F, Y658FJAK3: Q503H, Q507P/H, M511I, A572V, A573V, R629D, 630del, L653F, R657Q/W, V658F, V674F/A, V678L, V722I, Y824D, L857P	STAT5B: N642H, R659C, Y665H, Q706L	IL-2RG: M270 del, K315E	25–27
EATL		STAT5B: N642H		23

J. Chen, Y. Zhang, M. Petrus, W. Xiao, A. Nicolae, et al., submitted manuscript.

Abbreviations: AITL, angioimmunoblastic T cell lymphoma; ALCL, anaplastic large cell lymphoma; ALL, acute lymphoblastic leukemia; ATLL, adult T cell leukemia/lymphoma; CTCL, cutaneous T cell lymphoma; EATL, enteropathy-associated T cell lymphoma; ETP, acute lymphoblastic leukemia; γδTCL, γδ T cell lymphoma; HTLV-1, human T cell lymphotropic virus 1; LGL, large granulocytic leukemia; NKTCL, natural killer cell lymphoma; PTCL-NOS, peripheral T cell lymphoma not otherwise specified; T-PLL, T cell prolymphocytic leukemia.