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. 2021 Mar 8;23(5):336. doi: 10.3892/mmr.2021.11975

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Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — sFRP-4 inhibits the Wnt/β-catenin signaling pathway in HCC. GSK-3β and β-catenin protein expression levels in HCCLM3 and Huh7 cells transfected with sFRP-4-OE, si-sFRP-4 or NC were (A) determined via western blotting and (B) semi-quantified. (C) GSK-3β, β-catenin and sFRP-4 protein expression levels in HCCLM3 and Huh7 cells following treatment with IM-12 or DMSO for 36 h were determined via western blotting and semi-quantified. Data were analyzed using one-way ANOVA followed by Bonferroni's post hoc test. Data are presented as the mean ± SD from three independent experiments. **P<0.001 vs. CON or DMSO. sFRP-4, secreted frizzled-related protein 4; HCC, hepatocellular carcinoma; OE, overexpression; si, small interfering RNA; NC, negative control (empty vectors and si-NC); CON, blank control.