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. 2021 Mar 9;23(5):338. doi: 10.3892/mmr.2021.11977

Figure 2.

Figure 2.

Effect of Cy-3-g on inflammatory responses and oxidative stress in rats with pulmonary artery hypertension. Rats were randomly assigned into four groups (n=15): Control group, model group (MCT), Cy-3-g-L group and Cy-3-g-H group. On the first day of the experiments, the rats in the MCT, Cy-3-g-L and Cy-3-g-H groups were injected with MCT (60 mg/kg). On days 2–28, the rats in the Cy-3-g-L and Cy-3-g-H groups received a gavage of 200 and 400 mg/kg body weight, respectively. (A) mRNA level of IL-6, TNF-α and IL-10 in the lung tissue of rats. (B) ELISA analysis of protein levels of IL-6, TNF-α and IL-10 in the plasma of rats. Changes in (C) SOD activity and (D) MAD content in the plasma of rats. (E) mRNA and (F) protein expression of vWF, ICAM-1 and VCAM-1 in the lung tissue of rats. Data are shown as the mean ± SD. *P<0.05 vs. control; #P<0.05 vs. MCT. MCT, monocrotaline; Cy-3-g, cyanidin-3-O-β-glucoside; L, low-dose; H, high-dose; IL, interleukin; TNF, tumor necrosis factor; SOD, superoxide dismutase; MAD, malondialdehyde; vWF, von Willebrand factor; ICAM-1, intercellular adhesion molecule-1; VCAM-1, vascular adhesion molecule-1.