Table 2.
Patients' characteristics of 559 multiple myeloma patients in GSE24080.
| FSCN1 | FSCN2 | |||||
|---|---|---|---|---|---|---|
| Low (n = 279) | High (n = 280) | p-value | Low (n = 279) | High (n = 280) | p-value | |
| Age, mean (range) | 56.92 (29.7-76.5) | 57.44 (24.83-75) | 0.200 | 56.31 (24.83-76.5) | 58.05 (30.5-75) | 0.020 |
| Gender, no (%) | ||||||
| female | 116 (41.58) | 106 (37.86) | 0.417 | 124 (44.44) | 98 (35) | 0.028 |
| male | 163 (58.42) | 174 (62.14) | 155 (55.56) | 182 (65) | ||
| Race, no (%) | ||||||
| other | 31 (11.11) | 31 (11.07) | 1.000 | 37 (13.26) | 25 (8.93) | 0.135 |
| white | 248 (88.89) | 249 (88.93) | 242 (86.74) | 255 (91.07) | ||
| ISS, no (%) | ||||||
| I | 171 (61.07) | 147 (52.69) | 0.091 | 169 (60.36) | 149 (53.41) | 0.078 |
| II | 59 (21.07) | 63 (22.58) | 62 (22.14) | 60 (21.51) | ||
| Ⅲ | 50 (17.86) | 69 (24.73) | 49 (17.5) | 70 (25.09) | ||
| B2M (mean(sd)) | 5.29 (6.295) | 4.19 (4.171) | 0.015 | 5.351 (6.209) | 4.129 (4.281) | 0.007 |
| CRP (mean(sd)) | 12.328 (26.743) | 10.934 (18.34) | 0.473 | 11.698 (17.113) | 11.563 (27.534) | 0.944 |
| CREAT (mean(sd)) | 1.36 (1.322) | 1.286 (1.216) | 0.494 | 1.426 (1.438) | 1.219 (1.068) | 0.054 |
| LDH (mean(sd)) | 171.065 (71.332) | 172.886 (60.189) | 0.744 | 181.828 (73.813) | 162.161 (55.424) | <0.001 |
| ALB (mean(sd)) | 4.042 (0.559) | 4.056 (0.605) | 0.780 | 4.056 (0.585) | 4.042 (0.58) | 0.774 |
| HGB (mean(sd)) | 10.961 (1.794) | 11.545 (1.785) | <0.001 | 11.104 (1.752) | 11.401 (1.86) | 0.052 |
| ASPC (mean(sd)) | 47.842 (23.14) | 37.568 (23.249) | <0.001 | 44.143 (24.639) | 41.247 (22.702) | 0.149 |
| BMPC (mean(sd)) | 52.326 (25.13) | 40.515 (25.38) | <0.001 | 48.5 (26.52) | 44.298 (25.137) | 0.055 |
| MRI (mean(sd)) | 9.962 (12.728) | 12.111 (15.194) | 0.070 | 12.062(14.582) | 10.049 (13.443) | 0.090 |
| Cytogenetic abnormality (%) | ||||||
| No | 151 (54.12) | 201 (71.79) | <0.001 | 157 (56.27) | 195 (69.64) | 0.001 |
| Yes | 128 (45.88) | 79 (28.21) | 122 (43.73) | 85 (30.36) | ||
| ISOTYPE, no (%) | ||||||
| FLC | 52 (18.57) | 32 (11.47) | 0.112 | 35(12.5) | 49 (17.56) | 0.694 |
| IgA | 57 (20.36) | 76 (27.24) | 67(23.93) | 66 (23.66) | ||
| IgD | 2 (0.71) | 1 (0.36) | 1(0.36) | 2 (0.72) | ||
| IgG | 156 (55.71) | 157 (56.27) | 165(58.93) | 148 (53.05) | ||
| Nonsecretory | 3 (1.07) | 3 (1.08) | 2(0.71) | 4 (1.43) | ||
| NSE | 2 (0.71) | 0 (0) | 1(0.36) | 1 (0.36) | ||
| High CCND1, no (%) | 138 (49.46) | 142 (50.71) | 0.565 | 135 (48.39) | 145 (51.79) | 0.679 |
| High LIG4, no (%) | 139 (49.82) | 141 (50.36) | 0.746 | 140 (50.18) | 140 (50) | 0.308 |
| High TP53, no (%) | 150 (53.76) | 130 (46.43) | 0.378 | 143 (51.25) | 137 (48.93) | 0.620 |
| High CDK4, no (%) | 147 (52.69) | 133 (47.5) | 0.312 | 152 (54.48) | 128 (45.71) | 0.651 |
| High FGFR3, no (%) | 140 (50.18) | 140 (50) | 0.213 | 113 (40.5) | 167 (59.64) | 0.009 |
| High CDK5, no (%) | 138 (49.46) | 142 (50.71) | 0.943 | 143 (51.25) | 137 (48.93) | 0.721 |
| High HK2, no (%) | 152 (54.48) | 128 (45.71) | 0.478 | 145 (51.97) | 135 (48.21) | 0.142 |
Abbreviations: ALB: abumin (35 g/l); ASPC: Aspirate plasma cells (%); BMPC: Bone marrow biopsy plasma cells (%); B2M: beta-2 microglobulin (mg/l); CREAT: creatinine (mg/dl); CRP: C-reactive protein (mg/l); HGB: hemoglobin (g/dl); ISS: International Staging System; LDH: lactate dehydrogenase (U/l); MRI: number of magnetic resonance imaging (MRI)-defined focal lesions (skull, spine, pelvis); no: number of patients.