Table 1.
Top 30 DEGs by GSEA analysis
| Gene symbol | Gene name | Fold change; GPRC5A, high/low | Location | Protein function |
|---|---|---|---|---|
| SMAD4 | SMAD family member 4 | -0.91 | Nucleus/cytosol | Transcription factor |
| RFXAP | Regulatory factor X associated protein | -0.96 | Nucleus | Transcription factor |
| HSF2 | Heat shock transcription factor 2 | -0.74 | Nucleus | Transcription factor |
| ZBTB40 | Zinc finger and BTB domain containing 40 | -0.68 | Nucleus | Transcription factor |
| PITX1 | Paired like homeodomain 1 | 4.43 | Nucleus | Transcription factor |
| MACC1 | Metastasis-associated in colon cancer protein 1 | 2.04 | Nucleus/mitochondrion | Transcription activator |
| MAP2K4 | Mitogen-activated protein kinase kinase 4 | -0.58 | Nucleus/cytosol | Kinase |
| RHOF | Rho in filopodia | 2.65 | Extracellular/cytosol/cytoskeleton | GTPase |
| SESN1 | Sestrin 1 | -1.21 | Nucleus/cytosol | Enzyme |
| PRKN | Parkin RBR E3 ubiquitin protein ligase | -1.16 | Nucleus/cytosol/mitochondrion | Enzyme |
| ELAC1 | ElaC ribonuclease Z 1 | -1.01 | Nucleus/cytosol | Enzyme |
| SRR | Serine racemase | -0.87 | Cytosol | Enzyme |
| HELQ | Helicase POLQ like | -0.51 | Nucleus | Enzyme |
| ACSL5 | Acyl-CoA synthetase long chain family member 5 | 2.12 | Membrane/nucleus/mitochondrion | Enzyme |
| GJB3 | Gap Junction Protein Beta 3 | 4.43 | Membrane | Transporter |
| ANXA2 | Annexin A2 | 1.61 | Membrane/nucleus/extracellular | Transporter |
| CDIP1 | Cell death inducing p53 target 1 | -1.24 | Endosome/lysosome/membrane | Other |
| KLHL22 | Kelch like family member 22 | -0.86 | Cytosol | Other |
| RFESD | Rieske domain-containing protein | -0.83 | Unknown | Other |
| ELP5 | Elongator acetyltransferase complex subunit 5 | -0.71 | Nucleus/cytosol | Other |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 1.37 | Membrane/golgi apparatus | Other |
| JUP | Junction plakoglobin | 1.53 | Membrane/nucleus | Other |
| LMO7 | LIM domain 7 | 1.54 | Nucleus/cytosol | Other |
| OSBPL3 | Oxysterol binding protein like 3 | 1.64 | Nucleus/cytosol | Other |
| KRT19 | Keratin 19 | 2.89 | Extracellular/cytosol/cytoskeleton | Other |
| LGALS3 | Galectin 3 | 1.83 | Membrane/extracellular/nucleus | Other |
| MAL2 | Mal, T cell differentiation protein 2 | 1.97 | Membrane | Other |
| VILL | Villin like | 2.66 | Cytosol/cytoskeleton | Other |
| SFTA2 | Surfactant associated 2 | 5.12 | Extracellular/golgi apparatus | Other |
| SELENOP | Selenoprotein P | -1.31 | Extracellular | Other |