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. 2021 Jan 30;12(7):1967–1977. doi: 10.7150/jca.52455

Figure 2.

Figure 2

Aberrantly down-regulated expression of miR-16 and inverse correlation between miR-16 and VEGF expression in high-risk MDS. (A) CD34+cells from MDS patients and healthy controls were used to extract total RNA. RT-PCR of miR-15a revealed both lower-risk and higher-risk MDS patients had significantly higher miR-15a levels compared with normal controls. (B) RT-PCR of miR-16 revealed the expression level of miR-16 was remarkably lower in higher-risk MDS patients compared with normal controls and lower-risk patients. (C) Correlation analysis between miR-16 expression levels and VEGF expression levels in MDS lower-risk patients. (D) Correlation analysis between miR-16 expression levels and VEGF expression levels in MDS higher-risk patients. * P<0.05, **P<0.01.