Table 3.

Secretion of angiogenic factors from control and transfected SKM-1 cells

CM of SKM-1 cells	VEGF (pg/106 cells/ml) (mean ± SD)	bFGF (pg/106 cells/ml) (mean ± SD)	CTGF (pg/106 cells/ml) (mean ± SD)	MMP-2(pg/106 cells/ml) (mean ± SD)
Non-transfected cells	82.7 ±3.1	62.1±2.9	1.61±0.28	10.2±0.9
miRNA precursor control	83.4 ±3.2	68.9±3.4	1.65±0.09	11.1±1.3
mimics-miR-16	30.9±4.9***	63.6±3.4	1.51±0.29	10.8±1.9
inhibitor-miR-16	102.7±6.7**	62.9±3.9	1.75±0.22	10.4±0.8

(***P<0.001, **P<0.01) CM: culture media; VEGF: Vascular endothelial growth factor; b-FGF: basic fibroblast growth factor; CTGF: connective tissue growth factor; MMP-2: matrix metalloproteinase-2.