Table 4.
Univariate and multivariate Cox regression analysis of factors associated with overall survival
| Factors | Unmatched comparison | Matched comparison | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Univariate analysis | Univariate analysis | Univariate analysis | |||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Gender | ||||||||
| Male | Ref | Ref | ||||||
| Female | 0.908 (0.318-2.773) | 0.908 | 0.923 (0.265-3.214) | 0.900 | ||||
| Age (y) | ||||||||
| ≤65 | Ref | Ref | ||||||
| >65 | 1.083 (0.483-2.420) | 0.846 | 2.320 (0.857-6.276) | 0.098 | ||||
| BMI (kg/m2) | ||||||||
| 18.5-24 | Ref | Ref | ||||||
| >24 | 0.710 (0.328-1.538) | 0.385 | 2.222 (0.783-6.311) | 0.134 | ||||
| NRS 2002 score | ||||||||
| 1-2 | Ref | Ref | Ref | Ref | ||||
| 3-4 | 1.687 (0.719-3.955) | 0.229 | 1.142 (0.470-2.771) | 0.770 | 1.698 (0.540-5.341) | 0.366 | 2.588 (0.579-11.570) | 0.213 |
| 5-6 | 3.106 (1.061-9.091) | 0.039* | 1.647 (0.533-5.083) | 0.386 | 6.180 (1.301-28.055) | 0.018* | 12.968 (1.780-94.495) | 0.011* |
| ASA grade | ||||||||
| 1-2 | Ref | Ref | ||||||
| 3-4 | 1.217 (0.497-2.983) | 0.667 | 2.085 (0.599-7.257) | 0.248 | ||||
| Hypertension | ||||||||
| No | Ref | Ref | ||||||
| Yes | 0.507 (0.229-1.123) | 0.094 | 0.743 (0.275-2.010) | 0.559 | ||||
| Diabetes mellitus | ||||||||
| No | Ref | Ref | ||||||
| Yes | 0.418 (0.143-1.226) | 0.112 | 0.959 (0.275-3.342) | 0.948 | ||||
| Previous abdominal surgery | ||||||||
| No | Ref | Ref | ||||||
| Yes | 1.643 (0.612-4.408) | 0.324 | 0.829 (0.110-6.256) | 0.856 | ||||
| Tumor location | ||||||||
| Cardia | Ref | Ref | ||||||
| Body | 1.102 (0.274-4.435) | 0.891 | 1.071 (0.208-5.521) | 0.935 | ||||
| Antrum | 1.182 (0.391-3.569) | 0.767 | 0.717 (0.155-3.323) | 0.671 | ||||
| Total | 3.909 (0.699-21.861) | 0.121 | 6.520 (0.582-72.979) | 0.128 | ||||
| Differentiated degree | ||||||||
| Differentiated | Ref | Ref | ||||||
| Undifferentiated | 1.214 (0.400-3.680) | 0.732 | 1.310 (0.293-5.864) | 0.724 | ||||
| Signet ring carcinoma | 1.257 (0.460-3.433) | 0.655 | 1.033 (0.291-3.601) | 0.960 | ||||
| Pathological type | ||||||||
| Ulcerative type | Ref | Ref | ||||||
| Non-ulcerative type | 0.865 (0.256-2.925) | 0.816 | 1.732 (0.395-7.596) | 0.467 | ||||
| TNM stage | ||||||||
| I | Ref | Ref | Ref | Ref | ||||
| II | 9.633 (1.154-80.384) | 0.036* | 9.815 (1.174-82.049) | 0.035* | 4.758 (0.871-25.995) | 0.072 | 5.686 (0.737-43.861) | 0.095 |
| III | 14.208 (1.898-106.340) | 0.010* | 10.735 (1.386-83.148) | 0.023* | 10.492 (2.321-47.434) | 0.002* | 17.492 (2.445-125.157) | 0.004* |
| Combined organ resection | ||||||||
| No | Ref | Ref | ||||||
| Yes | 1.630 (0.381-6.969) | 0.510 | 2.425 (0.321-18.315) | 0.391 | ||||
| Laparoscopic gastrectomy | ||||||||
| No | Ref | Ref | Ref | Ref | ||||
| Yes | 0.135 (0.018-1.002) | 0.050* | 0.178 (0.024-1.343) | 0.094 | 0.280 (0.091-0.859) | 0.026* | 0.264 (0.077-0.905) | 0.034* |
BMI body mass index; ASA American Society of Anesthesiologists, NRS 2002 nutritional risk screening 2002, TNM tumor-node-metastasis.
*Statistically significant (P < 0.05).