Table 2.

Genes exhibiting significant differential expression in PfRH5-specific CXCR5⁺CD4⁺ T cells from ChAd63-MVA versus protein/AS01_B vaccinees

Gene name	log2 fold changea	pb	padjc
Genes significantly elevated in PfRH5-specific CXCR5+cells from ChAd63-MVA versus protein/AS01Bvaccinees (padj < 0.05)
LAMP3	2.272789216	6.58E−10	9.52E−6
EPSTI1	1.965551847	1.60E−9	1.16E−5
SAMD9L	1.767361405	2.59E−9	1.25E−5
PARP9	1.445906493	6.26E−9	2.26E−5
GBP1	1.728592469	2.16E−7	6.25E−4
PARP14	1.08386039	5.00E−7	9.97E−4
MT2A	1.055914157	5.51E−7	9.97E−4
NEXN	2.367357699	6.47E−7	1.04E−3
GBP4	1.416953658	1.04E−6	1.50E−3
GBP1P1	2.222556141	1.71E−6	2.20E−3
XAF1	1.979815403	1.82E−6	2.20E−3
IFI44	1.859295207	2.38E−6	2.65E−3
IFI44L	2.192709426	3.77E−6	3.54E−3
PARP12	1.089549049	7.07E−6	5.39E−3
MX1	2.011280932	7.07E−6	5.39E−3
CD38	1.827598259	9.29E−6	6.40E−3
OAS2	1.488737846	1.10E−5	7.24E−3
IFIH1	1.204575617	1.59E−5	9.98E−3
ETV7	1.520984294	1.91E−5	1.15E−2
CXCL11	2.197707279	2.57E−5	1.48E−2
BCL2L14	1.893427738	3.12E−5	1.67E−2
IFI27	2.013182177	4.51E−5	2.22E−2
IFI6	1.827966249	4.60E−5	2.22E−2
GPATCH1	0.77259541	4.93E−5	2.30E−2
CPNE8	1.242453104	8.09E−5	3.55E−2
PARP11	0.560307668	8.54E−5	3.64E−2
Genes significantly reduced in PfRH5-specific CXCR5+cells from ChAd63-MVA versus protein/AS01Bvaccinees (padj < 0.05)
TPGS2	−0.591165012	4.24E−7	9.97E−4
FLJ21408	−1.456625333	3.46E−6	3.54E−3
TPP1	−0.665841538	3.92E−6	3.54E−3
FCGRT	−1.211341921	4.34E−6	3.70E−3
ICAM5	−2.31437469	8.14E−6	5.89E−3
ADAM8	−0.685269989	2.71E−5	1.51E−2
LOC113230	−1.523476907	3.99E−5	2.06E−2
CRTAP	−0.834799548	7.69E−5	3.48E−2
C11orf35	−1.380148661	1.12E−4	4.65E−2

FDR, false discovery rate.

^aElevation or reduction in ChAd63-MVA versus protein/AS01_B vaccinees.

^bDifference between groups, unadjusted p value.

^cFalse discovery rate (FDR) adjp value. Only genes for which padj < 0.05 are listed.