Fig 1.

Illustration of the changes that axons undergo owing to cytoskeletal perturbation from mild traumatic brain injury.

A, The top neuron is healthy. In the bottom neuron, neurofilamentous and, generally, cytoskeletal misalignment is visible a short time after injury. This impairs axonal transport.

B, Organelles accumulate in the injured region, causing the axon to swell locally and subsequently disconnect from the rest. In this Figure, the dimensions of the axons relative to the interaxonal space do not necessarily correspond to reality.