Fig 1.

CT scans and data analysis obtained from patient 1.

A, Representative images from the dynamic contrast-enhanced CT study. Top row, Before the administration of contrast material, a subtle tumoral hyperattenuation indicates hemorrhage (arrow). Middle row, After the injection of contrast agent, the tumor is immediately and strongly enhancing. Bottom row, The tumor remains hyperattenuating even after the contrast agent washes out.

B, Time-attenuation curve of the tumor from the ROI in the bottom right image in A. Strong enhancement of approximately 15 HU is present during the first pass. A slight decrease in tumoral attenuation is followed by steady enhancement during the equilibrium phase. Contrast-agent washout is not observed during the studied period of approximately 5 minutes.

C–E, Pixel-by-pixel parameter maps of CBV (C), CBF (D) and PS area (E) in the section in A. CBV is slightly increased in the tumor and decreased in the surrounding edematous tissue. No increase in blood flow is seen. Tumoral conspicuity is highest on the PS map (arrow), against the near-zero permeability of the normal brain tissue.