Table 2.
The correlation between TL levels and clinical characteristics, 5hmC levels and TET genes expression
| Samples | TN TL ratio | ||||
|---|---|---|---|---|---|
| Characteristics | Overall (%) | < 0.3 | > 0.3 | P | |
| Age | ≤ 65 | 78 (37.0%) | 27 | 51 | |
| > 65 | 133 (63.0%) | 54 | 79 | 0.464 | |
| Sex | female | 33 (15.6%) | 15 | 18 | |
| male | 178 (84.4%) | 66 | 112 | 1 | |
| Smoking status | smoker | 173 (82.0%) | 67 | 106 | |
| non smoker | 38 (18.0%) | 14 | 24 | 0.856 | |
| Alcohol exposure | drinker | 170 (80.6%) | 61 | 109 | |
| non drinker | 41 (19.4%) | 20 | 21 | 1 | |
| Tumor size | T1-2 | 78 (37.0%) | 29 | 49 | |
| T3-4 | 133 (63.0%) | 52 | 81 | 0.884 | |
| Lympho-node status | N0 | 75 (35.5%) | 28 | 47 | |
| N+ | 136 (64.5%) | 53 | 83 | 0.883 | |
| Stage | I, II, III | 75 (35.5%) | 31 | 44 | |
| IV | 136 (64.5%) | 50 | 86 | 1 | |
| Recurrence events | positive | 71 (33.6%) | 38 | 33 | |
| negative | 140 (66.4%) | 43 | 97 | 0.002* | |
| TN 5hmC ratio | high | 34 (19.1 %) | 14 | 38 | |
| low | 144 (80.9 %) | 55 | 71 | 0.043* | |
| TN TET1 expression ratio | high | 66 (60.0 %) | 20 | 46 | |
| low | 44 (40.0 %) | 18 | 26 | 1 | |
| TN TET2 expression ratio | high | 66 (60.0 %) | 22 | 44 | |
| low | 44 (40.0 %) | 16 | 28 | 1 | |
| TN TET3 expression ratio | high | 64 (58.2 %) | 19 | 45 | |
| low | 46 (41.8 %) | 19 | 27 | 0.228 | |
| Frequency of TET1, TET2 and TET3 low expression | 0 | 47 (42.7%) | 11 | 36 | |
| 1-3 | 63 (57.3%) | 27 | 36 | 0.043* | |
† Fisher's exact probability test. * P<0.05.