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. 2021 Mar 1;12(8):2430–2439. doi: 10.7150/jca.53385

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Enhanced expression of HOXC8 reverses the proliferation and migration inhibition of T24 and SW780 cells induced by suppressing circNT5E. (A) The expression level of HOXC8 mRNA in T24 and SW780 cells transfected with pcDNA3.1-HOXC8. (B-E) The results of CCK-8 and colon formation assay showed suppression of circNT5E notably impaired Bca cell proliferation, and the suppressive phenomenon was rescued after cells were co-transfected with pcDNA3.1-HOXC8. (F, G) Cell migration assay showed that suppression of circNT5E notably impaired Bca cell migration, and the suppressive phenomenon was rescued after cells were co-transfected with pcDNA3.1-HOXC8. *P < 0.05, **P < 0.01 and NS: none significant.