Figure 2.

The expression of CDK1 in normal endometrium tissues and endometrioid endometrial cancer tissues. (A) Representative different types of immunostaining for CDK1 in normal endometrium tissues and endometrioid endometrial cancer tissues (original magnification×400). (a) CDK1-negative nuclear and cytoplasmic staining in the majority of normal endometrium tissues. (b) CDK1-positive nuclear staining but CDK1-negative cytoplasmic staining in the minority of normal endometrium tissues. (c) CDK1 strong positive nuclear staining but CDK1 weak positive cytoplasmic staining in the well differentiated endometrioid endometrial cancer tissues. (d) Diffuse strong positive staining for CDK1 in moderately differentiated endometrioid endometrial cancer tissues. (B) The average IHC scores in the nucleus and cytoplasm of normal endometrium tissues (n = 30) were compared with the scores in the nucleus and cytoplasm of cancer tissues (n = 33). Student's independent t-tests was used. Data were presented as means ± SD, ****p <0.0001. (C) Representative immunohistochemical staining for CDK1 in normal endometrium tissues and its matched adjacent cancer tissues. Representative immunostaining for CDK1 in normal endometrium tissues (a) and its matched adjacent cancer tissues (b) of endometrioid endometrial cancer (original magnification×400). (c) A geographic zone of normal endometrium tissues (upper and left) contrasting with matched adjacent region of cancer tissues (down and right half) (original magnification×200). (d) Higher power view of the central region of panel C (original magnification×400). Scale bars 100 µm. (D) The average IHC scores in the nucleus and cytoplasm of normal endometrium tissues (n = 33) were compared with the scores in the nucleus and cytoplasm of matched adjacent cancer tissues (n = 33). Student's paired t-tests was used. Data were presented as means ± SD, ****p <0.0001.