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. 2021 Feb 22;12(8):2206–2215. doi: 10.7150/jca.51139

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RO3306 inhibited the growth of HEC-1-B cells in vivo. (A) The increment of xenograft tumor volume over time in xenograft models of HEC-1-B cells with two different treatments (vehicle or RO3306). Drugs were oral gavage administered once every 2 days and DMSO was served as vehicle control. The data shown represent mean ± SD from four samples (*p <0.05; **p <0.01; ***p <0.001; ****p <0.0001). (B) The changes of body weight of mice in two groups (the control group and the RO3306 treatment group). The data shown represent mean ± SD from four samples (p >0.05). (C) The tumor weights of the two groups (the control group and the RO3306 treatment group) at the end of the study (*p < 0.05). (D) Gross images of xenograft tumor masses of the two groups (the control group and the RO3306 treatment group) at the end of the study.