TABLE 3:
Dose Group and Time Point | Total Lymph Nodes | Quantitative Signal Intensity Measurements by Sequence* |
|||
---|---|---|---|---|---|
T1-Weighted | T2-Weighted | FFE-25 | FFE-80 | ||
1.1 mg Fe/kg | |||||
Predose | 18 | 486.1 + 45.8 | 536.0 + 64.6 | 1170.6 + 179.3 | 784.9 + 98.8 |
6 h | 18 | 626.6 + 70.3 | 277.1 + 45.4 | 995.6 + 129.4 | 510.6 + 69.7 |
12 h | 18 | 587.9 + 53.7 | 297.3 + 55.1 | 906.4 + 197.1 | 524.3 + 143.6 |
24 h | 18 | 596.9 + 98.2 | 280.1 + 34.7 | 904.7 + 178.9 | 442.4 + 117.7 |
36 h | 18 | 570.3 + 92.2 | 323.0 + 40.5 | 852.9 + 231.4 | 447.3 + 137.9 |
1.7 mg Fe/kg | |||||
Predose | 18 | 498.5 + 59.0 | 505.5 + 48.6 | 979.7 + 283.4 | 669.5 + 139.8 |
6 h | 15 | 618.7 + 89.1 | 256.1 + 67.0 | 901.3 + 257.9 | 473.8 + 167.6 |
12 h | 18 | 555.2 + 81.3 | 275.8 + 35.4 | 725.7 + 276.5 | 372.5 + 150.3 |
24 h | 18 | 567.9 + 101.0 | 279.9 + 74.6 | 676.7 + 266.4 | 341.7 + 135.5 |
36 h | 18 | 545.0 + 93.0 | 291.5 + 46.6 | 491.3 + 171.6 | 311.7 + 137.6 |
2.6 mg Fe/kg | |||||
Predose | 18 | 470.3 + 55.4 | 561.2 + 71.6 | 1150.0 + 125.2 | 777.1 + 95.2 |
6 h | 18 | 568.1 + 80.0 | 293.8 + 54.5 | 754.2 + 148.1 | 493.3 + 116.5 |
12 h | 18 | 534.7 + 109.7 | 225.7 + 50.4 | 535.6 + 93.6 | 328.1 + 64.1 |
24 h | 18 | 511.3 + 85.4 | 196.6 + 42.7 | 335.2 + 85.9 | 243.2 + 66.5 |
36 h | 18 | 494.6 + 119.3 | 209.2 + 41.9 | 316.3 + 79.4 | 188.4 + 48.6 |
3.4 mg Fe/kg | |||||
Predose | 18 | 515.0 + 76.9 | 583.6 + 140.7† | 1132.2 + 164.7 | 827.2 + 129.3 |
6 h | 18 | 608.3 + 68.8 | 276.8 + 110.9† | 710.8 + 166.4 | 550.6 + 117.9 |
12 h | 18 | 559.9 + 74.9 | 219.8 + 63.9† | 452.5 + 125.3 | 346.5 + 72.2 |
24 h | 18 | 513.1 + 68.6 | 178.3 + 58.7† | 326.2 + 98.4 | 255.4 + 76.9 |
36 h | 18 | 459.4 + 108.4 | 206.8 + 69.8† | 300.6 + 72.6 | 221.9 + 35.5 |
10 d | 6 | 487.7 + 58.2 | 570.9 + 113.2‡ | 594.1 + 80.6 | 530.8 + 103.8 |
1 mo | 6 | 457.8 + 81.2 | 561.3 + 115.4‡ | 726.9 + 450.8 | 617.3 + 185.4 |
3 mo | 6 | 502.6 + 14.0 | 595.3 + 27.7‡ | 965.2 + 272.3 | 895.8 + 181.5 |
Data are the mean + the SD.
The total number of lymph nodes was 17.
The total number of lymph nodes was 5.