TABLE 2:
Characteristics of neurotoxic events and MRI findings
| Patient | Time between Diagnosis and Event (months) | Event | Time between IT MTX and Event (days) | Time between Event and Initial MRI (days) | 1st MRI DWI Findings | Time between Initial and Follow-up MRI (days) | Follow-up MRI FLAIR Findings | Duration of Symptoms |
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | R hemiparesis, headache, dysmetria | 8 | 0 | Restricted L > R | 5 | Increased | 1 mo |
| 2 | 8 | Aphasia, headache, R hemiparesis | 7 | 1 | Restricted L > R | ND | ND | 4 d |
| 3 | 5 | L hemiparesis | 11 | 1 | Restricted R > L | 59 | Increased | 7 d |
| 4 | 11 | R hemiparesis | 6 | 1 | Restricted L only | 4 | Increased | 7 d |
| 5 | 11 | R hemiparesis | 7 | 2 | Restricted L > R | 20 | Increased | 7 d |
| 6 | 3 | Aphasia | 11 | 1 | Restricted R = L | 23 | Increased | 1 d |
Note.—R indicates right; L, left; IT MTX, intrathecal methotrexate; DWI, diffusion-weighted imaging; ND, not done; FLAIR, fluid attenuated inversion recovery sequence.