TABLE 2:
Imaging findings in six children with thiamine deficiency
| PatientNo. | Date ofMR | Periaqueductal | DW | Brain stem | DW | Tectum | MammillaryBodies | Thalami | DW | Caudate | DW | Putamen | DW | Frontal Cortexand WM | DW | VolumeLoss |
| 1 | 25.9.03 | − | N | − | N | + | + | − | N | − | N | − | N | − | N | − |
| 1.10.03 | + | C,V | + | N | + | + | + | C,V | + | C | + | C | + | C | − | |
| 7.11.03 | +Imp | N | − | N | Necrosis | Atrophy | +Necrosis | N | Hem Atrophy Necrosis | N | Hem Atrophy Necrosis | N | Laminar necrosis Leukomalacia | N | + | |
| 2 | 5.11.03 | + | N | + | C | − | + | + | C | − | C | − | N | + | C | − |
| B1→ | ||||||||||||||||
| 10.11.03 | − | NA | − | NA | − | + | +Imp | NA | − | NA | − | NA | Imp cortex | NA | − | |
| 26.11.03 | − | N | + | N | − | Atrophy | − | N | − | N | − | N | Laminar necrosis Leukomalacia | N | + | |
| 3 | 3.11.03 | + | NA | − | NA | − | − | + | NA | − | NA | + | NA | + | NA | + |
| B1→ | ||||||||||||||||
| 17.11.03 | +Imp | N | − | N | − | Atrophy | +Imp | N | +Worse | C | + | C | +Imp | N | Worse | |
| 4 | 25.9.03 | + | V | + | N | − | + | + | V | − | N | + | N | + | V | + |
| 8.11.03 | − | N | − | N | − | − | Imp | N | + | N | + | N | +Imp | N | Worse | |
| 5 | 6.11.03 | − | N | − | N | − | NA | − | N | − | N | − | N | − | C | − |
| 6 | 13.10.03 | + | N | − | N | − | + | + | N | − | N | + | N | + | N | − |
| B1→ | ||||||||||||||||
| 17.11.03 | − | N | − | N | − | − | − | N | − | N | Necrosis | N | + | N | − | |
| 9.2.04 | − | N | − | N | − | − | − | N | − | N | Atrophy | N | + | N | + |
Note.—+ indicates high signals on T2, FLAIR, or PD; −, normal signals; DW, diffusion-weighted images; C, cytotoxic edema; V, vasogenic edema; WM, white matter; NA, not available. N, normal or no signs of acute edema; Imp, improvement; Hem, hemorrhage; B1, start of treatment with B1.