Table 1.
Main characteristics of patients with cervical cancer undergoing FSS.
| LLETZ/CKC/ST | VRT | ART | ||
|---|---|---|---|---|
| Laparotomic | MIS | |||
| Study/patient characteristics | ||||
| n of studies | 29 | 31 | 28 | 10 |
| Total n of patients | 2540 | 2477 | 2268 | 566 |
| n of patients excluded # | 108 | 76 | 91 | 32 |
| Age (y), median (range) | 32 (22–46) | 31 (21–42) | 32 (22–40) | 31 (22–40) |
| Tumor characteristics ^ | n of patients (%) | n of patients (%) | n of patients (%) | n of patients (%) |
| FIGO stage * | ||||
| IA1 | 1551 (60.4) | 248 (9.0) | 165 (7.1) | 13 (2.4) |
| IA2 | 547 (21.3) | 311 (11.3) | 218 (9.4) | 50 (9.3) |
| IA-IB | 0 | 230 (8.4) | 143 (6.2) | 0 |
| IB1 | 452 (17.6) | 1933 (70.3) | 1723 (74.6) | 453 (84.0) |
| IB2 | 18 (0.7) | 3 (0.1) | 20 (0.9) | 3 (0.6) |
| IB nos | 0 | 0 | 17 (0.7) | 19 (3.5) |
| IIA | 2 (0.1) | 26 (0.9) | 25 (1.1) | 1 (0.2) |
| Histological subtype | ||||
| SCC | 2316 (82.2) | 1906 (67.9) | 1689 (72.4) | 339 (63.2) |
| AC | 467 (16.6) | 770 (27.4) | 518 (22.2) | 169 (31.5) |
| ASCC | 25 (0.9) | 86 (3.1) | 84 (3.6) | 12 (2.2) |
| Other | 8 (0.3) | 47 (1.7) | 43 (1.8) | 16 (3.0) |
| LVSI~ | 150/784 (19.1) | 586/1877 (31.2) | 657/1628 (40.4) | 59/341 (17.3) |
FSS—fertility-sparing surgery; LLETZ—large loop excision of transformation zone; CKC—cold knife conization; ST—simple trachelectomy; VRT—vaginal radical trachelectomy; ART—abdominal radical trachelectomy; MIS—minimal invasive surgery (laparoscopic or robot-assisted); SCC—squamous cell carcinoma; AC—adenocarcinoma; ASCC—adenosquamous cell carcinoma; LVSI—lymph-vascular space invasion; nos—not otherwise specified; # No FSS due to positive lymph nodes/margins or other reasons contraindicating FSS; ^ In some studies, this also includes excluded patients or patients who underwent other types of FSS if data were not reported separately; therefore, the n of patients could exceed the total n of patients; * FIGO 2009 classification was used in all but one study, which used FIGO 2018 (n = 32); ~limited to publications with available data.