Table 4.
Oncological and reproductive outcome after FSS in patients with cervical, ovarian, and endometrial cancer.
| Cervical Cancer | Ovarian Cancer | Endometrial Cancer | ||||
|---|---|---|---|---|---|---|
| LLETZ/CKC/ST | VRT | ART | ||||
| Laparotomic | MIS | |||||
| Oncological outcome * | ||||||
| Recurrence | 28/785 (3.6) | 82/1973 (4.2) | 47/1520 (3.1) | 15/335 (4.5) | 171/1084 (15.7) | 297/855 (34.7) |
| Died of disease | 6/785 (0.8) | 34/1973 (1.7) | 23/1520 (1.5) | 7/479 (1.5) | 489/3318 (14.7) | 5/648 (0.8) |
| Complete response | – | – | – | – | – | 736/918 (80.2) |
| Persistent disease | – | – | – | – | – | 182/918 (19.8) |
| PR | – | – | – | – | – | 16/504 (3.2) |
| SD | – | – | – | – | – | 52/504 (10.3) |
| PrD | – | – | – | – | – | 28/504 (5.6) |
| Follow-up in months, | 53 (9–137) | 52 (9–131) | 47 (12–120) | 44 (10–98) | 66 (38–143) | 56 (17–92) |
| median (range) | ||||||
| Fertility outcome * | ||||||
| Pregnancy wish ^ | 148/305 (48.5) | 599/1089 (55.0) | 510/1062 (48.0) | 71/199 (35.7) | 148/335 (44.2) | 279/446 (62.6) |
| Pregnancies ^ | 241/612 (39.4) | 707/1539 (45.9) | 353/1635 (21.6) | 81/344 (23.5) | 280/750 (37.3) | 256/505 (50.7) |
| Pregnant patients ^ | 196/665 (29.5) | 512/1392 (36.8) | 255/1427 (17.9) | 58/317 (18.3) | 207/701 (29.5) | 261/708 (36.9) |
| Pregnancy rate # | 82/138 (59.4) | 361/546 (66.1) | 212/471 (45.0) | 42/71 (59.2) | 110/148 (74.3) | 161/241 (66.8) |
| Fetal loss ~ | 36/234 (15.4) | 147/686 (21.4) | 101/407 (24.8) | 19/81 (23.5) | 17/191 (8.9) | 67/214 (31.3) |
| Termination ~ | 7/234 (3.0) | 26/686 (3.8) | 20/407 (4.9) | 0/81 (0) | 3/191 (1.6) | 0/214 (0) |
| Live birth ~ | 181/234 (77.4) | 484/686 (70.6) | 236/407 (58.0) | 58/81 (71.6) | 236/264 (89.4) | 172/239 (72.0) |
| Term delivery $ | 111/181 (61.3) | 262/484 (54.1) | 80/236 (33.9) | 26/58 (44.8) | 161/164 (98.2) | 82/93 (88.2) |
| Preterm delivery $ | 27/181 (14.9) | 146/484 (30.2) | 109/236 (46.2) | 32/58 (55.2) | 3/164 (1.8) | 9/93 (9.7) |
| Not specified | 43 | 76 | 47 | 0 | 72 | 79 |
| Pregnancy ongoing | 10 | 20 | 25 | 4 | 7 | 2 |
n/total (%); ^ total patients; # total patients with pregnancy wish who succeeded; ~ total pregnancies; $ total live births; LLETZ—large loop excision of the transformation zone; CKC—cold knife conization; ST—simple trachelectomy; VRT—vaginal radical trachelectomy; ART—abdominal radical trachelectomy; MIS—minimal invasive surgery (laparoscopic or robot-assisted); PR—partial response; SD—stable disease; PrD—progressive disease; * Limited to publications with available data.