Table 3.

Central Nervous System (CNS) Standardized Daily Dose Within 6 Days Before Outcome According to Medication Class

CNS Medication Class	Controls, n = 1,264	Cases, n = 316	P-Value1
	Mean±Standard Deviation, Median (Interquartile Range)
Antidepressant (serotonin norepinephrine reuptake inhibitor, selective serotonin reuptake inhibitor, tricyclic antidepressant)	0.88 ± 1.51, 0 (0–1.50)	0.81 ± 1.36, 0 (0–1.58)	.46
Antiepileptic	0.25 ± 0.60, 0 (0–0)	0.24 ± 0.56, 0 (0–0)	.78
Antipsychotic	0.74 ± 2.59, 0 (0–0)	1.02 ± 4.62, 0 (0–0.25)	.16
Benzodiazepine receptor agonist	0.36 ± 1.47, 0 (0–0)	0.34 ± 1.07, 0 (0–0)	.83
Opioids receptor agonists	1.08 ± 3.22, 0 (0–0.67)	1.99 ± 5.13, 0.11 (0–2.0)	<.001
All CNS medications	3.32 ± 4.97, 1.91 (0.25–4.01)	4.41 ± 7.25, 2.50 (0.50–5.75)	.002

¹Conditional logistic regression model