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. Author manuscript; available in PMC: 2021 Mar 19.
Published in final edited form as: Nat Med. 2020 Nov 9;26(12):1912–1918. doi: 10.1038/s41591-020-1103-1

Table 2 |.

Key regression results

Dependent variable IV n β r2 P
SSD PS_SZ 802 0.56 0.053 4.37 × 10−8*
Sub-threshold psychosis 755 0.24 0.01 0.0247
Baseline FSIQ 720 −0.096 0.0077 0.018
VIQ decline 396 0.66 0.051 0.00509*
SSD PS_IQ 802 −0.30 0.020 7.15 × 10−4*
Sub-threshold psychosis 755 −0.18 0.0072 0.056
Baseline FSIQ 720 0.20 0.038 1.08 × 10−7*
VIQ decline 396 −0.096 0.0013 0.658

Results are adjusted for standard covariates as described in Methods. β is the standard regression effect size estimate. r2 denotes the difference between model fit with or without independent variable (IV), using either standard r2 from linear regression or Nagelkerke pseudo r2. Nominal P values are reported. Asterisk (*) indicates a significant result after Bonferroni correction for eight independent main analyses in this study (two polygenic scores and four phenotypes).