TABLE 1:
FA values in three patients with PBD and age-matched control subjects
| FA values × 10−3 | 12 Months |
16 Months |
80 Months |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient |
Control |
Diff. | Patient |
Control |
Diff. | Patient |
Control |
Diff. | ||||||||
| Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | |||||
| White matter lateral to cerebellar | R | 293 (45) | 24 | 282 (36) | 35 | 12 | 308 (46) | 26 | 424 (47) | 28 | −116‡ | 471 (66) | 40 | 559 (74) | 73 | −88‡ |
| dentate nucleus | L | 324 (43) | 33 | 358 (68) | 31 | −34* | 303 (43) | 29 | 410 (72) | 31 | −107‡ | 461 (66) | 57 | 490 (90) | 56 | −29* |
| Cerebellar peduncle | R | 660 (46) | 12 | 814 (48) | 12 | −153‡ | 753 (46) | 12 | 788 (66) | 12 | −35 | 812 (59) | 12 | 872 (42) | 12 | −60† |
| L | 751 (80) | 12 | 882 (26) | 12 | −130‡ | 713 (67) | 12 | 800 (48) | 12 | −86† | 595 (39) | 12 | 849 (70) | 12 | −254‡ | |
| Cerebral peduncle | R | 526 (106) | 39 | 677 (79) | 15 | −151‡ | 584 (96) | 46 | 608 (128) | 35 | −24 | 515 (90) | 37 | 722 (125) | 76 | −207‡ |
| L | 591 (65) | 26 | 585 (93) | 34 | 6 | 608 (129) | 37 | 642 (86) | 34 | −34 | 552 (77) | 49 | 727 (84) | 50 | −175‡ | |
| Optic radiation | R | 364 (35) | 12 | 562 (32) | 12 | −198‡ | 507 (50) | 12 | 599 (27) | 12 | −92‡ | 605 (32) | 12 | 625 (51) | 12 | −20 |
| L | 455 (45) | 12 | 520 (58) | 12 | −65† | 487 (27) | 12 | 639 (74) | 12 | −152‡ | 505 (65) | 12 | 740 (93) | 12 | −235‡ | |
| Genu of internal capsule | R | 539 (32) | 12 | 637 (79) | 12 | −98‡ | 611 (37) | 12 | 604 (41) | 12 | 7 | 544 (31) | 12 | 777 (53) | 12 | −233‡ |
| L | 561 (15) | 12 | 582 (44) | 12 | −21 | 630 (39) | 12 | 652 (69) | 12 | −22 | 658 (44) | 12 | 809 (54) | 12 | −151‡ | |
| Posterior limb of internal capsule | R | 564 (99) | 83 | 666 (97) | 66 | −102‡ | 634 (144) | 111 | 671 (117) | 69 | −37 | 613 (85) | 124 | 734 (81) | 79 | −121‡ |
| L | 572 (88) | 92 | 657 (79) | 58 | −85‡ | 676 (101) | 114 | 686 (75) | 76 | −10 | 663 (83) | 107 | 747 (81) | 98 | −84‡ | |
| Anterior limb of internal capsule | R | 493 (75) | 48 | 511 (87) | 30 | −18 | 476 (95) | 57 | 547 (85) | 38 | −71‡ | 487 (81) | 42 | 676 (125) | 39 | −189‡ |
| L | 508 (113) | 48 | 575 (68) | 18 | −67* | 508 (86) | 62 | 599 (101) | 33 | −91‡ | 556 (114) | 79 | 594 (107) | 41 | −38 | |
| Genu of corpus callosum | 599 (72) | 12 | 732 (60) | 12 | −133‡ | 544 (46) | 12 | 908 (58) | 12 | −364‡ | 532 (88) | 12 | 779 (101) | 12 | −247‡ | |
| Splenium of corpus callosum | 532 (57) | 12 | 523 (77) | 12 | 9 | 695 (26) | 12 | 893 (32) | 12 | −198‡ | 618 (57) | 12 | 608 (104) | 12 | 10 | |
| Parietal corona radiata | R | 207 (33) | 51 | 247 (75) | 51 | −40‡ | 237 (54) | 51 | 301 (54) | 51 | −64‡ | 240 (41) | 51 | 270 (89) | 51 | −30* |
| L | 162 (54) | 51 | 199 (77) | 51 | −37† | 170 (41) | 51 | 280 (57) | 51 | −110‡ | 245 (59) | 51 | 379 (77) | 51 | −134‡ | |
| Frontal corona radiata | R | 214 (31) | 51 | 227 (54) | 51 | −13 | 232 (42) | 51 | 327 (52) | 51 | −95‡ | 362 (97) | 51 | 423 (79) | 51 | −61‡ |
| L | 184 (71) | 51 | 221 (78) | 51 | −37* | 252 (64) | 51 | 249 (84) | 51 | 3 | 339 (101) | 51 | 403 (120) | 51 | −64† | |
| Centrum semiovale | R | 317 (28) | 51 | 427 (109) | 51 | −110‡ | 432 (80) | 51 | 465 (62) | 51 | −33* | 446 (150) | 51 | 559 (76) | 51 | −113‡ |
| L | 318 (27) | 51 | 407 (77) | 51 | −89‡ | 388 (54) | 51 | 526 (82) | 51 | −138‡ | 442 (158) | 51 | 507 (76) | 51 | −65† | |
Note.—N indicates number of pixels per region of interest; significance determined with t test:
*
P < .05;
†
P < .01;
‡
P < .001.