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. 2021 Jan 31;17(3):689–701. doi: 10.7150/ijbs.53667

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Irradiation reduces the survival of BRCA1-down-regulated and -mutated tumor cells. (A) MCF7 cells were transfected with control or BRCA1 siRNA, and then treated with the indicated dose of irradiation. Irradiation-induced survival was estimated using MTT assays. (B) The survival of Brca1^Δ^11/^Δ¹¹53bp1^-/- (triangle) and Brca1^Δ^11/^Δ¹¹Tp53^-/- (circle) mammary tumor cell lines was estimated in the presence of the indicated dose of irradiation. Each number represents survival relative to that in the absence of irradiation (**P < 0.01). (C) MCF7, Brca1^Δ^11/^Δ¹¹53bp1^-/- and Brca1^Δ^11/^Δ¹¹Tp53^-/- mammary tumor cells were exposed to irradiation (10 Gy) and their protein expression patterns were analyzed by Western blotting. β-Actin was detected as a loading control.