Table 1:
MD and FA histogram-derived measures of brain tissue, gray matter, and white matter from patients with RNMO and control subjects
| RNMO | Controls | P* (95% CI) | |
|---|---|---|---|
| Brain tissue | |||
| Average MD (×10−3 mm2 s−1) | 0.946 ± 0.022 | 0.909 ± 0.031 | <.001 |
| (0.934–0.958) | (0.893–0.925) | (0.018 to 0.056) | |
| Mean MD peak height (‰) | 10.326 ± 0.657 | 11.224 ± 1.260 | .017 |
| (9.975–10.676) | (10.552–11.895) | (−1.624 to −0.172) | |
| Mean MD peak location (×10−3 mm2 s−1) | 0.777 ± 0.022 | 0.764 ± 0.025 | .136 |
| (0.765–0.789) | (0.751–0.778) | (−0.004 to 0.030) | |
| Average FA | 0.250 ± 0.008 | 0.253 ± 0.009 | .356 |
| (0.246–0.254) | (0.248–0.258) | (−0.009 to 0.003) | |
| Mean FA peak height (‰) | 4.109 ± 0.213 | 4.090 ± 0.272 | .828 |
| (3.996–4.222) | (3.945–4.235) | (−0.157 to 0.195) | |
| Mean FA peak location | 0.127 ± 0.009 | 0.125 ± 0.010 | .577 |
| (0.123–0.132) | (0.120–0.131) | (−0.005 to 0.009) | |
| White matter | |||
| Average MD (×10−3 mm2 s−1) | 0.822 ± 0.016 | 0.803 ± 0.019 | .004 |
| (0.813–0.830) | (0.793–0.812) | (0.007 to 0.032) | |
| Mean MD peak height (‰) | 15.856 ± 0.889 | 16.310 ± 1.402 | .283 |
| (15.382–16.329) | (15.563–17.057) | (−1.301 to 0.393) | |
| Mean MD peak location (×10−3 mm2 s−1) | 0.760 ± 0.022 | 0.744 ± 0.019 | .042 |
| (0.748–0.771) | (0.734–0.754) | (0.001 to 0.030) | |
| Average FA | 0.333 ± 0.012 | 0.345 ± 0.016 | .020 |
| (0.327–0.339) | (0.336–0.353) | (−0.022 to −0.002) | |
| Mean FA peak height (‰) | 2.614 ± 0.179 | 2.383 ± 0.180 | .001 |
| (2.519–2.709) | (2.288–2.480) | (0.101 to 0.360) | |
| Mean FA peak location | 0.216 ± 0.034 | 0.254 ± 0.063 | .043 |
| (0.199–0.234) | (0.221–0.288) | (−0.074 to −0.001) | |
| Gray matter | |||
| Average MD (×10−3 mm2 s−1) | 1.057 ± 0.037 | 0.992 ± 0.053 | <.001 |
| (1.037–1.077) | (0.964–1.020) | (0.032 to 0.098) | |
| Mean MD peak height (‰) | 7.368 ± 0.889 | 8.913 ± 1.707 | .003 |
| (6.894–7.842) | (8.003–9.822) | (−2.527 to −0.562) | |
| Mean MD peak location (×10−3 mm2 s−1) | 0.833 ± 0.016 | 0.809 ± 0.017 | <.001 |
| (0.825–0.842) | (0.800–0.818) | (0.013 to 0.036) |
Note:—RNMO indicates relapsing neuromyelitis optica; MD, mean diffusivity; FA, fractional anisotropy. Values are expressed as means ± SD (95% confidence interval).
*
Statistical analysis: Student t test for independent samples; P < .005 is considered significant.